8/3/2023 1 Comment Group 1 mr contrast agent![]() ![]() The potential risk factors for CIE may include chronic hypertension, renal dysfunction, history of stroke, high-contrast osmolality, and overdose of contrast medium ( 3– 8). The mechanisms of CIE remain unclear, and it is speculated that increased permeability of the blood–brain barrier (BBB), hyperosmolarity, and direct neurotoxicity from the contrast agents may lead to CIE ( 5). The clinical manifestations mainly include encephalopathy, cortical blindness, motor deficit, decreased vigilance, aphasia, headache, and epileptic seizures ( 4). It has been reported to occur in 1.7–3.6% of neurological endovascular procedures, including cerebral angiography, coil embolization, and endovascular thrombectomy procedure ( 1– 3). Pearson contingency coefficients and logistic regression showed a significant correlation between general anesthesia and the risk of CIE.Ĭonclusion: General anesthesia might be a risk factor for CIE, and propofol might be associated with the increased occurrence of CIE.Ĭontrast-induced encephalopathy (CIE) is a rare neurological complication following the administration of contrast agents in various angiographic procedures. After propensity score-based matching of CIE, the anesthesia methods were significantly different between the two groups. After propensity score-based matching of anesthesia methods, the occurrence of CIE was significantly different between the general anesthesia and local anesthesia group ( P = 0.007). In total, 14 patients were identified as CIE, resulting in a total incidence rate of 1.34%. A total of 370 patients (35.5%) received treatment under local anesthesia, while the remaining 673 (64.5%) underwent treatment under general anesthesia. Results: In this study, we implemented the embolization of intracranial aneurysm in 412 patients, stent implantation of extracranial artery stenosis in 346, stent implantation of intracranial artery stenosis in 187, embolization of cerebral arteriovenous malformation or dural arteriovenous fistula in 54, endovascular thrombectomy in 20, and other endovascular treatments in 24. A propensity score-based matching strategy and logistic regression were used to analyze the association between anesthesia and the occurrence of CIE. Methods: We retrospectively reviewed available clinical data from 1,043 patients with neurovascular diseases undergoing endovascular treatment between June 2018 and June 2021 in our hospital. The goal of this study was to investigate the incidence of CIE in patients who underwent endovascular treatment under different anesthesia methods and anesthetics administration and to explore whether general anesthesia was a potential risk factor for CIE. Although many potential risk factors for CIE have been reported, it is still unclear whether anesthesia is a risk factor for the occurrence of CIE. Objective: Contrast-induced encephalopathy (CIE) is a rare neurological complication that can occur in the context of various endovascular procedures. Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ![]() Zhihong Zhong †, Hongyang Ni †, Jun Zhu, Hong Jiang, Jinqing Hu, Dong Lin * and Liuguan Bian ![]()
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